Insulin resistance in children

VM Tagi, C Giannini, F Chiarelli - Frontiers in endocrinology, 2019 - frontiersin.org
Insulin resistance (IR) is a pathological condition strongly associated with obesity. However,
corticosteroids or growth hormone therapy and genetic diseases may affect insulin …

Insulin-resistance in paediatric age: Its magnitude and implications

M Al-Beltagi, AS Bediwy… - World journal of diabetes, 2022 - pmc.ncbi.nlm.nih.gov
Insulin resistance (IR) is insulin failure in normal plasma levels to adequately stimulate
glucose uptake by the peripheral tissues. IR is becoming more common in children and …

Recent developments in antimalarial drug discovery

T Umumararungu, JB Nkuranga, G Habarurema… - Bioorganic & Medicinal …, 2023 - Elsevier
Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

In Vitro and in silico studies to explore potent antidiabetic inhibitor against human pancreatic alpha-amylase from the methanolic extract of the green microalga …

S Sahoo, M Samantaray, M Jena, V Gosu… - Journal of …, 2024 - Taylor & Francis
Today's era and lifestyle have led to a quick rise in cases of diabetes. Diabetes mellitus (DM)
has risen to the top of the list of serious diseases and stems from different health disorders …

Phytochemical Profiling in Conjunction with In Vitro and In Silico Studies to Identify Human α-Amylase Inhibitors in Leucaena leucocephala (Lam.) De Wit for the …

S Renganathan, S Manokaran, P Vasanthakumar… - ACS …, 2021 - ACS Publications
Bioactive constituents from natural sources are of great interest as alternatives to synthetic
compounds for the treatment of various diseases, including diabetes mellitus. In the present …

c4c: Paediatric pharmacovigilance: Methodological considerations in research and development of medicines for children–A c4c expert group white paper

B Aurich, D Apele‐Freimane… - British journal of …, 2022 - Wiley Online Library
Children frequently respond differently to therapies compared to adults. Differences also
exist between paediatric age groups for pharmacokinetics and pharmacodynamics in both …

Utility of quantitative proteomics for enhancing the predictive ability of physiologically based pharmacokinetic models across disease states

S Sharma, D Suresh Ahire… - The Journal of Clinical …, 2020 - Wiley Online Library
Disease states such as liver cirrhosis and chronic kidney disease can lead to altered
pharmacokinetics (PK) of drugs by influencing drug absorption, blood flow to organs, plasma …

Effects of metformin on epicardial adipose tissue and atrial electromechanical delay of obese children with insulin resistance

H Güneş, H Güneş, Ş Özmen, E Çelik… - Cardiology in the …, 2020 - cambridge.org
Introduction: Obesity is usually related to insulin resistance and glucose metabolism
disorders. The relationship between insulin resistance and epicardial adipose tissue and …

[HTML][HTML] The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis

M Azhar, MS Alasmari, A Zamir, H Saeed… - …, 2025 - pmc.ncbi.nlm.nih.gov
Background/Objectives: Glimepiride (GLM), a commonly used sulphonylurea drug for the
management of type 2 diabetes mellitus (T2DM), has been the subject of numerous studies …

Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its …

W Feng, Y Liu, F Fei, Y Chen, Y Ding, M Yan, Y Feng… - RSC …, 2019 - pubs.rsc.org
Previous study has revealed that chromium malate could improve insulin resistance and the
regulation of fasting blood glucose in type 2 diabetic rats. This study was designed to …