In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling
and a therapeutic target in cardiac diseases. The recent discovery that cAMP is …

In order to analyze how a signal transduction network converts cellular inputs into cellular
outputs, ideally one would measure the dynamics of many signals within the network …

It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and
energy supply. Their unique morphological and functional features have recently brough …

Spatiotemporal regulation of intracellular signaling molecules, such as the 3′, 5′-cyclic
adenosine monophosphate (cAMP)-dependent protein kinase (PKA), ensures proper …

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …

Intracellular Ca 2+ is a key regulator of cell signaling and sperm are not the exception. Cells
often use cytoplasmic Ca 2+ concentration ([Ca 2+] i) oscillations as a means to decodify …

The ubiquitous secondary messengers, Ca 2+ and cAMP, play a vital role in sha** a
diverse array of physiological processes. More significantly, accumulating evidence over the …

Gi/o-coupled somatostatin or α2-adrenergic receptor activation stimulated β-cell NKA
activity, resulting in islet Ca2+ fluctuations. Furthermore, intra-islet paracrine activation of β …