The origin of the eukaryotic cell, with its compartmentalized nature and generally large size
compared with bacterial and archaeal cells, represents a cornerstone event in the evolution …

In this hypothesis article, we explore the origin of the eukaryotic nucleus. In doing so, we first
look afresh at the nature of this defining feature of the eukaryotic cell and its core functions …

The nature of the last universal common ancestor (LUCA), its age and its impact on the Earth
system have been the subject of vigorous debate across diverse disciplines, often based on …

Abstract Extremely halophilic archaea (Haloarchaea, Nanohaloarchaeota,
Methanonatronarchaeia and Halarchaeoplasmatales) thrive in saturating salt concentrations …

Executive summary Microbes are all pervasive in their distribution and influence on the
functioning and well‐being of humans, life in general and the planet. Microbially‐based …

Evolution of a complete nitrogen (N) cycle relies on the onset of ammonia oxidation, which
aerobically converts ammonia to nitrogen oxides. However, accurate estimation of the …

In this perspective, we explore the transformative impact and inherent limitations of
metagenomics and single-cell genomics on our understanding of microbial diversity and …

The existence of LUCA in the distant past is the logical consequence of the binary
mechanism of cell division. The biosphere in which LUCA and contemporaries were living …

The recently observed circadian oscillations of the intestinal microbiota underscore the
profound nature of the human–microbiome relationship and its importance for health …

Life is an exergonic chemical reaction. Many individual reactions in metabolism entail
slightly endergonic steps that are coupled to free energy release, typically as ATP …