CRISPR/Cas9 based systems have emerged as versatile platforms for precision genome
editing in a wide range of organisms. Here we have developed powerful CRISPR/Cas9 tools …

Profiling and structural elucidation of secondary metabolites produced by the filamentous
fungus Penicillium chrysogenum and derived deletion strains were used to identify the …

Filamentous fungi are historically known to be a rich reservoir of bioactive compounds that
are applied in a myriad of fields ranging from crop protection to medicine. The surge of …

We present a Penicillium rubens strain with an industrial background in which the four highly
expressed biosynthetic gene clusters (BGC) required to produce penicillin, roquefortine …

Background Penicillium chrysogenum is a filamentous fungus that is employed as an
industrial producer of β–lactams. The high β–lactam titers of current strains is the result of a …

Chrysogine is a yellow pigment produced by Penicillium chrysogenum and other
filamentous fungi. Although the pigment was first isolated in 1973, its biosynthetic pathway …

Penicillium chrysogenum is a filamentous fungus that is used to produce β‐lactams at an
industrial scale. At an early stage of classical strain improvement, the ability to produce the …

Naringenin is a natural product with several reported bioactivities and is the key
intermediate for the entire class of plant flavonoids. The translation of flavonoids into modern …

Abstract Background The yeast Saccharomyces cerevisiae is unable to ferment pentose
sugars like d-xylose. Through the introduction of the respective metabolic pathway, S …

Intense classical strain improvement has yielded industrial Penicillium chrysogenum strains
that produce high titers of penicillin. These strains contain multiple copies of the penicillin …