Biological activity of ionic liquids and their application in pharmaceutics and medicine
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …
modern science. Because of their highly tunable nature and exceptional properties, ionic …
Pre-nucleation clusters as solute precursors in crystallisation
Crystallisation is at the heart of various scientific disciplines, but still the understanding of the
molecular mechanisms underlying phase separation and the formation of the first solid …
molecular mechanisms underlying phase separation and the formation of the first solid …
Driving and characterizing nucleation of urea and glycine polymorphs in water
Crystal nucleation is relevant across the domains of fundamental and applied sciences.
However, in many cases, its mechanism remains unclear due to a lack of temporal or spatial …
However, in many cases, its mechanism remains unclear due to a lack of temporal or spatial …
Interaction anisotropy and shear instability of aspirin polymorphs established by nanoindentation
Nanoindentation is applied to the two polymorphs of aspirin to examine and differentiate
their interaction anisotropy and shear instability. Aspirin provides an excellent test system for …
their interaction anisotropy and shear instability. Aspirin provides an excellent test system for …
From crystal structure prediction to polymorph prediction: interpreting the crystal energy landscape
SL Price - Physical Chemistry Chemical Physics, 2008 - pubs.rsc.org
Many organic molecules are emerging as having many crystalline forms, including
polymorphs and solvates, as more techniques are being used to generate and characterise …
polymorphs and solvates, as more techniques are being used to generate and characterise …
Now you see them
How do crystals nucleate? According to classical nucleation theory, calcium carbonate
nucleation proceeds by addition of ions to a single cluster (top). Gebauer et al. now suggest …
nucleation proceeds by addition of ions to a single cluster (top). Gebauer et al. now suggest …
Glycine exists mainly as monomers, not dimers, in supersaturated aqueous solutions: Implications for understanding its crystallization and polymorphism
J Huang, TC Stringfellow, L Yu - Journal of the American Chemical …, 2008 - ACS Publications
Glycine, the simplest amino acid, is described as existing as hydrogen-bonded cyclic dimers
in supersaturated aqueous solutions and, as a result, crystallizing in a centrosymmetric …
in supersaturated aqueous solutions and, as a result, crystallizing in a centrosymmetric …
“CLASSIC NMR”: An In‐Situ NMR Strategy for Map** the Time‐Evolution of Crystallization Processes by Combined Liquid‐State and Solid‐State Measurements
CE Hughes, PA Williams, KDM Harris - Angewandte Chemie, 2014 - Wiley Online Library
A new in‐situ NMR strategy (termed CLASSIC NMR) for map** the evolution of
crystallization processes is reported, involving simultaneous measurement of both liquid …
crystallization processes is reported, involving simultaneous measurement of both liquid …
Pre-nucleation clusters predict crystal structures in models of chiral molecules
JE Carpenter, M Grunwald - Journal of the American Chemical …, 2021 - ACS Publications
Kinetics can play an important role in the crystallization of molecules and can give rise to
polymorphism, the tendency of molecules to form more than one crystal structure. Current …
polymorphism, the tendency of molecules to form more than one crystal structure. Current …
Polymorph formation and nucleation mechanism of tolfenamic acid in solution: an investigation of pre-nucleation solute association
A Mattei, T Li - Pharmaceutical research, 2012 - Springer
Purpose Crystallization from solution involves nucleation and growth; growth conditions
greatly influence self-association behaviors of solute molecules in these steps, affecting …
greatly influence self-association behaviors of solute molecules in these steps, affecting …