Large clostridial toxins: mechanisms and roles in disease

KE Orrell, RA Melnyk - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

Bacterial pathogenomics

MJ Pallen, BW Wren - Nature, 2007 - nature.com
Genomes from all of the crucial bacterial pathogens of humans, plants and animals have
now been sequenced, as have genomes from many of the important commensal, symbiotic …

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue

M Desvaux, M Hébraud, R Talon, IR Henderson - Trends in microbiology, 2009 - cell.com
Extracellular proteins are a subject of intense interest because of their essential roles in
bacterial lifestyles. However, several terms related to secretion are used confusingly in the …

Type IV pili in Gram-positive bacteria

S Melville, L Craig - Microbiology and molecular biology reviews, 2013 - Am Soc Microbiol
SUMMARY Type IV pili (T4P) are surface-exposed fibers that mediate many functions in
bacteria, including locomotion, adherence to host cells, DNA uptake (competence), and …

Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE

R Govind, B Dupuy - PLoS pathogens, 2012 - journals.plos.org
The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea,
is mainly associated with the production and activities of two major toxins. In many bacteria …

Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective

C Chagnot, MA Zorgani, T Astruc… - Frontiers in …, 2013 - frontiersin.org
Bacterial colonization of biotic or abiotic surfaces results from two quite distinct physiological
processes, namely bacterial adhesion and biofilm formation. Broadly speaking, a biofilm is …

Nutritional stress induces exchange of cell material and energetic coupling between bacterial species

S Benomar, D Ranava, ML Cárdenas, E Trably… - Nature …, 2015 - nature.com
Abstract Knowledge of the behaviour of bacterial communities is crucial for understanding
biogeochemical cycles and develo** environmental biotechnology. Here we demonstrate …

Protein cell surface display in Gram-positive bacteria: from single protein to macromolecular protein structure

M Desvaux, E Dumas, I Chafsey… - FEMS microbiology …, 2006 - academic.oup.com
In the course of evolution, Gram-positive bacteria, defined here as prokaryotes from the
domain Bacteria with a cell envelope composed of one biological membrane (monodermita) …

Molecular biology of surface colonization by Listeria monocytogenes: an additional facet of an opportunistic Gram‐positive foodborne pathogen

S Renier, M Hébraud, M Desvaux - Environmental …, 2011 - Wiley Online Library
The opportunistic and facultative intracellular pathogenic bacterium Listeria monocytogenes
causes a rare but severe foodborne disease called listeriosis, the outcome of which can be …

The enigmatic Esx proteins: looking beyond mycobacteria

M Unnikrishnan, C Constantinidou, T Palmer… - Trends in …, 2017 - cell.com
Bacteria export proteins across membranes using a range of transport machineries. Type VII
secretion systems (T7SSs), originally described in mycobacteria, are now known to be …