Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat …

J Li, T Wang, P Liu, F Yang, X Wang, W Zheng… - Food & function, 2021 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease.
Dietary supplementation has become a promising strategy for managing NAFLD …

Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

New insights and potential therapeutic interventions in metabolic diseases

VJ Clemente-Suárez, A Martín-Rodríguez… - International journal of …, 2023 - mdpi.com
Endocrine homeostasis and metabolic diseases have been the subject of extensive
research in recent years. The development of new techniques and insights has led to a …

Treatment for liver cancer: From sorafenib to natural products

S Man, C Luo, M Yan, G Zhao, L Ma, W Gao - European journal of …, 2021 - Elsevier
Liver cancer most commonly develops in patients with chronic liver disease, the etiology of
which includes viral hepatitis (B and C), alcohol, obesity, dietary carcinogens, and so forth …

Signaling pathways related to oxidative stress in diabetic cardiomyopathy

M Peng, Y Fu, C Wu, Y Zhang, H Ren… - Frontiers in …, 2022 - frontiersin.org
Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …

Epigenetics in NAFLD/NASH: Targets and therapy

N Sodum, G Kumar, SL Bojja, N Kumar… - Pharmacological …, 2021 - Elsevier
Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific
attention, owing to its rapid increase in prevalence worldwide and growing burden on end …

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

K Yang, J Chen, T Zhang, X Yuan, A Ge… - Frontiers in …, 2022 - frontiersin.org
Background Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a
novel direction, and the existing clinical studies have little effective evidence for its …

Progress in the treatment of drug-induced liver injury with natural products

Y Sun, Y Zhang, L **e, F Rong, X Zhu, J **e… - Pharmacological …, 2022 - Elsevier
There are numerous prescription drugs and non-prescription drugs that cause drug-induced
liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its …