Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Abstract Worldwide, an estimated 130–170 million people have HCV infection. HCV
prevalence is highest in Egypt at> 10% of the general population and China has the most …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …