The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

▪ Abstract The low-density lipoprotein (LDL) receptor (LDL-R) family consists of cell-surface
receptors that recognize extracellular ligands and internalize them for degradation by …

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process
in which the extracellular matrix (ECM) plays the dual role of the substratum on which the …

Cancer cells invade by secreting degradative enzymes, which are sequestered in lysosomal
vesicles. In this study, the impact of an acidic extracellular environment on lysosome size …

The GPI‐anchored urokinase plasminogen activator receptor (uPAR) does not internalize
free urokinase (uPA) but readily internalizes and degrades uPA: serpin complexes in a …

Cellular migration, over simple surfaces or through complex stromal barriers, requires
coordination between detachment/re‐adhesion cycles, involving structural components of …

The low-density lipoprotein receptor gene family is an evolutionarily conserved group of cell-
surface receptors produced by mammals and other organisms. Initially thought to be …

The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein
(LDL) receptor family. In vitro and in vivo studies have shown that VLDL receptor binds …

Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …