Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies

J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Characterization of Aβ monomers through the convergence of ensemble properties among simulations with multiple force fields

DJ Rosenman, C Wang, AE García - The Journal of Physical …, 2016 - ACS Publications
Amyloid β (Aβ) monomers represent a base state in the pathways of aggregation that result
in the fibrils and oligomers implicated in the pathogenesis of Alzheimer's disease (AD). The …

[BOOK][B] Biophysical characterization of intrinsically disordered peptides through molecular dynamics simulations and solution nuclear magnetic resonance …

DJ Rosenman - 2015 - search.proquest.com
Abstract Representing 20-30% of the human proteome, intrinsically disordered peptides
(IDPs) are highly dynamic sequences that do not assume a single, defined native state …