Asymptomatic malaria infections: detectability, transmissibility and public health relevance

T Bousema, L Okell, I Felger, C Drakeley - Nature Reviews Microbiology, 2014 - nature.com
Most Plasmodium falciparum infections that are detected in community surveys are
characterized by low-density parasitaemia and the absence of clinical symptoms. Molecular …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination

T Bousema, C Drakeley - Clinical microbiology reviews, 2011 - journals.asm.org
Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Submicroscopic Infection in Plasmodium falciparum-Endemic Populations: A Systematic Review and Meta-Analysis

LC Okell, AC Ghani, E Lyons… - The Journal of infectious …, 2009 - academic.oup.com
Introduction Light microscopy examination of blood slides is the main method of detecting
malaria infection; however, it has limited sensitivity. Low-density infections are most likely to …

Dynamics of the human infectious reservoir for malaria determined by mosquito feeding assays and ultrasensitive malaria diagnosis in Burkina Faso

A Lin Ouédraogo, BP Gonçalves… - The Journal of …, 2016 - academic.oup.com
Background Plasmodium falciparum gametocytes are essential for malaria transmission.
Malaria control measures that aim at reducing transmission require an accurate …

Substantial Contribution of Submicroscopical Plasmodium falciparum Gametocyte Carriage to the Infectious Reservoir in an Area of Seasonal Transmission

AL Ouédraogo, T Bousema, P Schneider, SJ de Vlas… - PloS one, 2009 - journals.plos.org
Background Man to mosquito transmission of malaria depends on the presence of the
sexual stage parasites, gametocytes, that often circulate at low densities. Gametocyte …

Targeting human transmission biology for malaria elimination

SK Nilsson, LM Childs, C Buckee, M Marti - PLoS pathogens, 2015 - journals.plos.org
Malaria remains one of the leading causes of death worldwide, despite decades of public
health efforts. The recent commitment by many endemic countries to eliminate malaria …

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea

C Koepfli, LJ Robinson, P Rarau, M Salib, N Sambale… - PloS one, 2015 - journals.plos.org
A better understanding of human-to-mosquito transmission is crucial to control malaria. In
order to assess factors associated with gametocyte carriage, 2083 samples were collected …

Assessing the infectious reservoir of falciparum malaria: past and future

W Stone, BP Gonçalves, T Bousema, C Drakeley - Trends in parasitology, 2015 - cell.com
Renewed interest in malaria eradication has placed greater emphasis on the development
of tools to interrupt Plasmodium transmission, such as transmission-blocking vaccines …

Predominance of asymptomatic and sub-microscopic infections characterizes the Plasmodium gametocyte reservoir in the Peruvian Amazon

E Rovira-Vallbona, JJ Contreras-Mancilla… - PLoS neglected …, 2017 - journals.plos.org
Malaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte
stages circulating in the human bloodstream. In the context of malaria elimination …