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COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease
D Tomasoni, L Italia, M Adamo… - European journal of …, 2020 - Wiley Online Library
Patients with cardiovascular disease and, namely, heart failure are more susceptible to
coronavirus disease 2019 (COVID‐19) and have a more severe clinical course once …
coronavirus disease 2019 (COVID‐19) and have a more severe clinical course once …
Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
C Lei, K Qian, T Li, S Zhang, W Fu, M Ding… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China,
at the end of 2019, and there are currently no specific antiviral treatments or vaccines …
at the end of 2019, and there are currently no specific antiviral treatments or vaccines …
[HTML][HTML] Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications
N Banu, SS Panikar, LR Leal, AR Leal - Life sciences, 2020 - Elsevier
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …
scientific community has joined forces to develop effective treatment strategies. The …
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis
AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
Targeting the renin-angiotensin-aldosterone system in fibrosis
M AlQudah, TM Hale, MP Czubryt - Matrix Biology, 2020 - Elsevier
Fibrosis is characterized by excessive deposition of extracellular matrix components such as
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …
Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin ii type i receptor–dependent mechanism
MR Deshotels, H **a, S Sriramula, E Lazartigues… - …, 2014 - ahajournals.org
Angiotensin-converting enzyme type 2 (ACE2) is a pivotal component of the renin–
angiotensin system, promoting the conversion of angiotensin II (Ang-II) to Ang-(1-7). We …
angiotensin system, promoting the conversion of angiotensin II (Ang-II) to Ang-(1-7). We …
ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis
ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …