[HTML][HTML] Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells

MI Khan, S Siddiqui, MA Barkat, FS Alhodieb… - Journal of Traditional …, 2022 - Elsevier
Introduction Moringa oleifera is known as a 'natural nutrition of the tropics' because it
provides vital nutritional supplements and a variety of pharmacological benefits. The focus of …

Structural and Functional Annotation of Hypothetical Proteins from the Microsporidia Species Vittaforma corneae ATCC 50505 Using in silico Approaches

LM Ang'ang'o, JK Herren, Ö Tastan Bishop - International Journal of …, 2023 - mdpi.com
Microsporidia are spore-forming eukaryotes that are related to fungi but have unique traits
that set them apart. They have compact genomes as a result of evolutionary gene loss …

Binding site characterization–similarity, promiscuity, and druggability

C Ehrt, T Brinkjost, O Koch - Medchemcomm, 2019 - pubs.rsc.org
The elucidation of non-obvious binding site similarities has provided useful indications for
the establishment of polypharmacology, the identification of potential off-targets, or the …

Exploring the binding affinity and non-covalent interactions of anthocyanins with aging-related enzymes through molecular docking

JSB Nas - Philippine Journal of Health Research and …, 2020 - pjhrd.upm.edu.ph
Abstract Background and Objective: Anthocyanins are associated with aging and longevity.
However, the mechanism involving the pure anthocyanin compounds in aging remains …

Specifics of metabolite-protein interactions and their computational analysis and prediction

D Walther - Cell-Wide Identification of Metabolite-Protein …, 2022 - Springer
Computational approaches to the characterization and prediction of compound-protein
interactions have a long research history and are well established, driven primarily by the …

Comparative assessment of the therapeutic drug targets of C. botulinum ATCC 3502 and C. difficile str. 630 using in silico subtractive proteomics approach

T Bhardwaj, S Haque… - Journal of Cellular …, 2019 - Wiley Online Library
Growing antimicrobial resistance of the pathogens against multiple drugs posed a serious
threat to the human health worldwide. This fueled the need of identifying the novel …

Identification of phytocompounds as potent inhibitors of sodium/glucose cotransporter-2 leading to diabetes treatment

A Swargiary, M Daimari, A Swargiary… - Journal of …, 2024 - Taylor & Francis
Type-II diabetes, a major metabolic disorder has threatened the very existence of a healthy
life since long ago. Commercially available antidiabetic drugs are known for several adverse …

Roles of Physicochemical and Structural Properties of RNA-Binding Proteins in Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning

L Zhu, W Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Trans-acting splicing factors play a pivotal role in modulating alternative splicing by
specifically binding to cis-elements in pre-mRNAs. There are approximately 1500 RNA …

Spatial proximity statistics suggest a regulatory role of protein phosphorylation on compound binding

P Korkuć, D Walther - Proteins: Structure, Function, and …, 2016 - Wiley Online Library
Phosphorylation is an important post‐translational modification that regulates protein
function by the attachment of negatively charged phosphate groups to phosphorylatable …

Anthocyanin-Binding Affinity and Non-Covalent Interactions with IIS-Pathway-Related Protein Through Molecular Docking

Z Khan, W Javaid, LX **ng - Current Issues in Molecular Biology, 2025 - mdpi.com
Anthocyanins compounds, including cyanidin, malvidin, pelargonidin, peonidin, and
petunidin, have demonstrated remarkable anti-aging and insulin-sensitizing properties …