Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on
aberrant genes and early neural hazards, but then it grew to include ideas concerning …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Background Polygenic risk score (PRS) analyses have become an integral part of
biomedical research, exploited to gain insights into shared aetiology among traits, to control …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how
combinations of genetic factors determine risk is unclear. In a large family sample, we show …

Sex differences in the human brain are of interest for many reasons: for example, there are
sex differences in the observed prevalence of psychiatric disorders and in some …

UK Biobank is a health resource with data from over 500,000 adults. The cognitive
assessment in UK Biobank is brief and bespoke, and is administered without supervision on …

Large-scale cross-sectional and cohort studies have transformed our understanding of the
genetic and environmental determinants of health outcomes. However, the …

Macroscopic cortical networks are important for cognitive function, but it remains challenging
to construct anatomically plausible individual structural connectomes from human …