Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

Mitochondrial fission and mitophagy are considered key processes involved in the
pathogenesis of cardiac microvascular ischemia reperfusion (IR) injury although the …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Organelles perform critical biological functions due to their distinct molecular composition
and internal environment. Disorders in organelles or their interacting networks have been …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Redox signalling in mitochondria plays an important role in myocardial
ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen …

Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and
consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric …

Endothelial cells (ECs) line the quiescent vasculature but can form new blood vessels (a
process termed angiogenesis) in disease. Strategies targeting angiogenic growth factors …

Mitochondria are ancient organelles that are thought to have emerged from once free-living
α-proto-bacteria. As such, they still possess several bacterial-like qualities, including a semi …