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Recent advances in the chemical synthesis and evaluation of anticancer nucleoside analogues
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …
Beyond the Pummerer reaction: recent developments in thionium ion chemistry
LHS Smith, SC Coote, HF Sneddon… - Angewandte Chemie …, 2010 - Wiley Online Library
Since the early 1960s the Pummerer reaction has evolved to become an indispensable tool
for synthesis, and continues to serve as a source of inspiration for organic chemists. In …
for synthesis, and continues to serve as a source of inspiration for organic chemists. In …
Pyrrolo [2, 1-c][1, 4] benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs
Compounds that bind in the minor groove of DNA have found use in the experimental
treatment of cancer and certain infectious diseases. Furthermore, agents which target and …
treatment of cancer and certain infectious diseases. Furthermore, agents which target and …
Recent advances in the synthesis of fluorinated nucleosides
XL Qiu, XH Xu, FL Qing - Tetrahedron, 2010 - Elsevier
Fluorine is one of the most abundant elements on earth. However, it occurs extremely rarely
in biological compounds. Due to the specific properties of fluorine atom (s), including small …
in biological compounds. Due to the specific properties of fluorine atom (s), including small …
Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues
Analogues of the canonical nucleosides required for nucleic acid synthesis have a
longstanding presence and proven capability within antiviral and anticancer research. 4 …
longstanding presence and proven capability within antiviral and anticancer research. 4 …
[HTML][HTML] Design, chemical synthesis and antiviral evaluation of 2′-deoxy-2′-fluoro-2′-C-methyl-4′-thionucleosides
Nucleoside analogues represent an historically accomplished class of antiviral drug.
Notwithstanding this, new molecular scaffolds are required to overcome their limitations and …
Notwithstanding this, new molecular scaffolds are required to overcome their limitations and …
A guide for the synthesis of key nucleoside scaffolds in drug discovery
DG Rajapaksha, S Mondal, JW Wang… - Medicinal Chemistry …, 2023 - Springer
This review aims to provide an overview of the synthetic strategies employed for generating
modifications within the sugar backbone of nucleoside analogs. We have focused our …
modifications within the sugar backbone of nucleoside analogs. We have focused our …
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential
A Kamal, P Reddy, DR Reddy, E Laxman… - Bioorganic & medicinal …, 2004 - Elsevier
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential - ScienceDirect
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A facile, alternative synthesis of 4 '-thioarabinonucleosides and their biological activities
Y Yoshimura, M Watanabe, H Satoh… - Journal of medicinal …, 1997 - ACS Publications
4 '-Thioarabinonucleosides, which are potential antiviral agents, were synthesized from d-
glucose. 1, 4-Anhydro-4-thioarabitol (8), which can be derived from diacetone glucose in …
glucose. 1, 4-Anhydro-4-thioarabitol (8), which can be derived from diacetone glucose in …