Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …

It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …

The synaptic tagging and capture hypothesis of protein synthesis-dependent long-term
potentiation asserts that the induction of synaptic potentiation creates only the potential for a …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …