Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human
cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the …

Nutrients and energy have emerged as central modulators of developmental programmes in
plants and animals,–. The evolutionarily conserved target of rapamycin (TOR) kinase is a …