Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

DNA and histone modifications combine into characteristic patterns that demarcate
functional regions of the genome,. While many 'readers' of individual modifications have …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Although cancer initiation and progression are generally associated with the accumulation
of somatic mutations,, substantial epigenomic alterations underlie many aspects of …

Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …