Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Background: Open Access Editor's Choice Review Monogenic Parkinson's Disease:
Genotype, Phenotype, Pathophysiology, and Genetic Testing by Fangzhi Jia 1, 2, Avi Fellner …

Mitochondrial mass and quality are tightly regulated by two essential and opposing
mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's
disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting …

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

This article provides an overview of the background knowledge of ferroptosis in the nervous
system, as well as the key role of nuclear factor E2-related factor 2 (Nrf2) in regulating …

Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …