Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

EE McClure, ASO Chávez, DK Shaw… - Nature Reviews …, 2017 - nature.com
It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

A metagenomic study of the gut microbiome in Behcet's disease

Z Ye, N Zhang, C Wu, X Zhang, Q Wang, X Huang… - Microbiome, 2018 - Springer
Background Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory disease that
can lead to irreversible blindness. Microbial agents have been considered to contribute to …

Rickettsia-Host-Tick Interactions: Knowledge Advances and Gaps

HK Kim - Infection and Immunity, 2022 - Am Soc Microbiol
Ticks are hematophagous ectoparasites capable of transmitting multiple human pathogens.
Environmental changes have supported the expansion of ticks into new geographical areas …

Iron robbery by intracellular pathogen via bacterial effector–induced ferritinophagy

Q Yan, W Zhang, M Lin… - Proceedings of the …, 2021 - National Acad Sciences
Iron is essential for survival and proliferation of Ehrlichia chaffeensis, an obligatory
intracellular bacterium that causes an emerging zoonosis, human monocytic ehrlichiosis …

Disentangling the taxonomy of Rickettsiales and description of two novel symbionts (“Candidatus Bealeia paramacronuclearis” and “Candidatus Fokinia cryptica”) …

F Szokoli, M Castelli, E Sabaneyeva… - Applied and …, 2016 - Am Soc Microbiol
In the past 10 years, the number of endosymbionts described within the bacterial order
Rickettsiales has constantly grown. Since 2006, 18 novel Rickettsiales genera inhabiting …

The enigmatic biology of rickettsiae: recent advances, open questions and outlook

J McGinn, RL Lamason - Pathogens and Disease, 2021 - academic.oup.com
Rickettsiae are obligate intracellular bacteria that can cause life-threatening illnesses and
are among the oldest known vector-borne pathogens. Members of this genus are …

Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen

AG Sanderlin, H Kurka Margolis, AF Meyer… - Nature …, 2024 - nature.com
Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their
infectious niche. Rickettsia spp. are obligate intracellular bacteria that can cause life …

Deianiraea, an extracellular bacterium associated with the ciliate Paramecium, suggests an alternative scenario for the evolution of Rickettsiales

M Castelli, E Sabaneyeva, O Lanzoni… - The ISME …, 2019 - academic.oup.com
Rickettsiales are a lineage of obligate intracellular Alphaproteobacteria, encompassing
important human pathogens, manipulators of host reproduction, and mutualists. Here we …

Pathogenic Rickettsia spp. as emerging models for bacterial biology

B Sit, RL Lamason - Journal of Bacteriology, 2024 - Am Soc Microbiol
Our understanding of free-living bacterial models like Escherichia coli far outpaces that of
obligate intracellular bacteria, which cannot be cultured axenically. All obligate intracellular …