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Digital twins for multiple sclerosis
An individualized innovative disease management is of great importance for people with
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …
Clinical course of multiple sclerosis
The 1996 originally established multiple sclerosis (MS) subtypes, based solely on clinical
impression and consensus, were revised in 2013 to review potential imaging and biological …
impression and consensus, were revised in 2013 to review potential imaging and biological …
How patients with multiple sclerosis acquire disability
Patients with multiple sclerosis acquire disability either through relapse-associated
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
Association of brain atrophy with disease progression independent of relapse activity in patients with relapsing multiple sclerosis
Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …
Silent progression in disease activity–free relapsing multiple sclerosis
University of California, San Francisco MS … - Annals of …, 2019 - Wiley Online Library
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis
(MS) may be substantially lower in actively treated patients compared to natural history …
(MS) may be substantially lower in actively treated patients compared to natural history …
Progressive multiple sclerosis: from pathogenic mechanisms to treatment
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …
disease mechanisms have led to the development of several disease-modifying therapies …
[HTML][HTML] Brain health: time matters in multiple sclerosis
Introduction We present international consensus recommendations for improving diagnosis,
management and treatment access in multiple sclerosis (MS). Our vision is that these will be …
management and treatment access in multiple sclerosis (MS). Our vision is that these will be …
Long‐term evolution of multiple sclerosis disability in the treatment era
University of California, San Francisco MS … - Annals of …, 2016 - Wiley Online Library
Objective To characterize the accrual of long‐term disability in a cohort of actively treated
multiple sclerosis (MS) patients and to assess whether clinical and magnetic resonance …
multiple sclerosis (MS) patients and to assess whether clinical and magnetic resonance …
Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies
DM Wingerchuk, JL Carter - Mayo Clinic Proceedings, 2014 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating central nervous system
disease that typically strikes young adults, especially women. The pathobiology of MS …
disease that typically strikes young adults, especially women. The pathobiology of MS …
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
V Brinkmann, A Billich, T Baumruker… - Nature reviews Drug …, 2010 - nature.com
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …