Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics
improve clinically important outcomes in critically ill adults with sepsis or septic shock …

Sepsis is a life-threatening organ dysfunction caused by an unregulated response of a host.
Septic shock is its most severe form. It is manifested by a drop in blood pressure, which …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Importance Whether β-lactam antibiotics administered by continuous compared with
intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective …

Delphi is a scientific method to organize and structure an expert discussion aiming to
generate insights on controversial topics with limited information. The technique has seen a …

Purpose Severe community-acquired pneumonia (CAP) requiring intensive care unit
admission is associated with significant acute and long-term morbidity and mortality. We …

Background Neutrophil-to-lymphocyte ratio (NLR) has been used to predict the prognosis of
patients with sepsis with inconsistent results. This meta-analysis aimed to clarify the …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …