Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Spatial omics technologies enable a deeper understanding of cellular organizations and
interactions within a tissue of interest. These assays can identify specific compartments or …

Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgrou**s gloss over the molecular, morphological, and circuit specificity of …

Predictive processing postulates the existence of prediction error neurons in cortex. Neurons
with both negative and positive prediction error response properties have been identified in …

The computational capabilities of neuronal networks are fundamentally constrained by their
specific connectivity. Previous studies of cortical connectivity have mostly been carried out in …

Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing,
spatial transcriptomics and long-term ex vivo tissue culture of surgically resected human …

The central nucleus of the amygdala (CEA) is a brain region that integrates external and
internal sensory information and executes innate and adaptive behaviors through distinct …