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[HTML][HTML] Ultrasound-responsive cavitation nuclei for therapy and drug delivery
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …
Ultrasound-guided drug delivery in cancer
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery
technology has shown that this approach can improve spatially confined delivery of drugs …
technology has shown that this approach can improve spatially confined delivery of drugs …
Nucleation, map** and control of cavitation for drug delivery
Acoustically driven bubbles produce a range of mechanical, thermal and chemical effects
that can be exploited in drug delivery applications. Significant improvements in the targeting …
that can be exploited in drug delivery applications. Significant improvements in the targeting …
A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening recently entered
clinical testing for targeted drug delivery to the brain. Sources of variability exist in the …
clinical testing for targeted drug delivery to the brain. Sources of variability exist in the …
Thermometry and ablation monitoring with ultrasound
In this review we present the current status of ultrasound thermometry and ablation
monitoring, with emphasis on the diverse approaches published in the literature and with an …
monitoring, with emphasis on the diverse approaches published in the literature and with an …
Quantitative frequency-domain passive cavitation imaging
Passive cavitation detection has been an instrumental technique for measuring cavitation
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …
Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …