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Multiple functions of DYRK2 in cancer and tissue development
Dual‐specificity tyrosine‐regulated kinases (DYRKs) are evolutionarily conserved from
yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in …
yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in …
Cilia kinases in skeletal development and homeostasis
Primary cilia are dynamic compartments that regulate multiple aspects of cellular signaling.
The production, maintenance, and function of cilia involve more than 1000 genes in …
The production, maintenance, and function of cilia involve more than 1000 genes in …
CircCOX6A1 suppresses osteogenic differentiation and aggravates osteoporosis via miR-512-3p/DYRK2 axis
D He, S Zheng, J Cao, J Deng, R Ding, Y Xu… - Molecular Biology …, 2024 - Springer
Background Osteoporosis (OP), characterized by compromised bone integrity and increased
fracture risk, poses a significant health challenge. Circular RNAs (circRNAs) have emerged …
fracture risk, poses a significant health challenge. Circular RNAs (circRNAs) have emerged …
[HTML][HTML] Preventing osteoporotic bone loss in mice by promoting balanced bone remodeling through M-CSFRGD, a dual antagonist to c-FMS and αvβ3 receptors
Y Zur, S Katchkovsky, A Itzhar… - International Journal of …, 2024 - Elsevier
Osteoporosis is a common, age-related disease caused by imbalanced bone remodeling.
Current treatments either shut down bone resorption or robustly stimulate bone formation …
Current treatments either shut down bone resorption or robustly stimulate bone formation …
Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors
Osteoclasts are the bone resorbing cells that derive from myeloid progenitor cells. Although
there have been recent advancements in the ability to identify osteoclast progenitors, very …
there have been recent advancements in the ability to identify osteoclast progenitors, very …
DYRK2 controls a key regulatory network in chronic myeloid leukemia stem cells
CS Park, HD Lacorazza - Experimental & Molecular Medicine, 2020 - nature.com
Chronic myeloid leukemia is a hematological cancer driven by the oncoprotein BCR-ABL1,
and lifelong treatment with tyrosine kinase inhibitors extends patient survival to nearly the …
and lifelong treatment with tyrosine kinase inhibitors extends patient survival to nearly the …
[CITA][C] The molecular mechanisms underlining osteoclast fusion in health and disease
G Guterman-Ram - 2017 - Ben-Gurion University of the Negev