Exosomal circRNAs: biogenesis, effect and application in human diseases

Y Wang, J Liu, J Ma, T Sun, Q Zhou, W Wang, G Wang… - Molecular cancer, 2019 - Springer
Exosomes have emerged as critical mediators of intercellular communication, both locally
and systemically, by regulating a diverse range of biological processes between cells …

Cancer stem cells as key drivers of tumour progression

AZ Ayob, TS Ramasamy - Journal of biomedical science, 2018 - Springer
Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

The origin and pathogenesis of endometriosis

Y Wang, K Nicholes, IM Shih - Annual Review of Pathology …, 2020 - annualreviews.org
Recent molecular genetic findings on endometriosis and normal endometrium suggest a
modified model in which circulating epithelial progenitor or stem cells intended to …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

KE Richards, AE Zeleniak, ML Fishel, J Wu… - Oncogene, 2017 - nature.com
Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic
ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus …

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

G Lou, Z Chen, M Zheng, Y Liu - Experimental & molecular medicine, 2017 - nature.com
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …

Extracellular vesicles: new classification and tumor immunosuppression

M Sheta, EA Taha, Y Lu, T Eguchi - Biology, 2023 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …

The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?

A Jurj, C Ionescu, I Berindan-Neagoe… - Journal of Experimental & …, 2022 - Springer
The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

A Conigliaro, V Costa, A Lo Dico, L Saieva, S Buccheri… - Molecular cancer, 2015 - Springer
Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC),
displaying aggressive and metastatic phenotype. Using two different in vitro models, already …

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

J **ao, Y Pan, XH Li, XY Yang, YL Feng, HH Tan… - Cell death & …, 2016 - nature.com
Cardiac progenitor cells derived from adult heart have emerged as one of the most
promising stem cell types for cardiac protection and repair. Exosomes are known to mediate …