[HTML][HTML] Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics

JL Rocha, RN Lou, PH Sudmant - Current opinion in genetics & …, 2024 - Elsevier
Highlights•T2T genomes are transforming our understanding of genome architecture and
evolution.•Population scale long read sequencing is identifying novel selective …

Balancing selection on genomic deletion polymorphisms in humans

A Aqil, L Speidel, P Pavlidis, O Gokcumen - Elife, 2023 - elifesciences.org
A key question in biology is why genomic variation persists in a population for extended
periods. Recent studies have identified examples of genomic deletions that have remained …

More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles

C Lockwood, AS Vo, H Bellafard, AJR Carter - Frontiers in Genetics, 2024 - frontiersin.org
Introduction Many loci segregate alleles classified as “genetic diseases” due to their
deleterious effects on health. However, some disease alleles have been reported to show …

Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries

N Sheng, L Mårell, RT Sitaram, G Svensäter… - …, 2024 - thelancet.com
Background Lifestyle-and sucrose-dependent polymicrobial ecological shifts are a primary
cause of caries in populations with high caries prevalence. In populations with low …

Gender Impacted Gut Microbiota and Growth Performance in the Blotched Snakehead (Channa maculata)

C Fang, F Zeng, S Chen, S Li, Y Yang, W Lin, Y Liu… - Microorganisms, 2024 - mdpi.com
The blotched snakehead Channa maculata is an important economical freshwater species
in East Asia. However, there has been relatively little research conducted on the correlation …

Personalized oral care (Precaries): an intervention study customized according to genetic cause and risk

A Westerlund, H Khalifa, R Yousif, G Araujo… - medRxiv, 2024 - medrxiv.org
Introduction Dental caries is a disease that affects billions of people, and involves high and
low genetic susceptibility phenotypes and different causal subtypes. The randomized clinical …