Metastatic colorectal cancer (CRC) with a mismatch repair-deficiency (MMR-
D)/microsatellite instability-high (MSI-H) phenotype carries unique characteristics such as …

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels,
cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating …

The natural history of a tumor includes phases of 'in situ'growth, invasion, extravasation and
metastasis. During these phases, tumor cells interact with their microenvironment and are …

Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in
genes encompassing coding microsatellites (cMS). This results in the translation of proteins …

The abundance of tumour‐infiltrating T‐cells has been associated with microsatellite
instability (MSI) and a favourable prognosis in colorectal cancer. However, numerous …

The aim of the study is the assessment of the intensity of the infiltration of tumor-associated
macrophages (TAMs) CD68+/iNOS− and Tregs CD8+/FoxP3+ in colorectal cancer (CRC) …

Regulatory T cells (Treg) inhibit the generation of host‐versus‐tumor immunity via
suppression of tumor‐specific effector T‐cell responses and development of immune …

Immune cells in the tumor microenvironment have an important role in regulating tumor
progression. Therefore, stimulating immune reactions to tumors can be an attractive …

Abstract The American Joint Committee on Cancer/Union Internationale Contre le Cancer
(AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor features …

Metastatic colorectal cancer is the fourth most common cause of cancer death. Current
options in palliation such as hyperthermic intraperitoneal chemotherapy (HIPEC) present …