Image-based profiling for drug discovery: due for a machine-learning upgrade?
Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …
biological images is reduced to a multidimensional profile, a collection of extracted image …
[HTML][HTML] Chemical probes and drug leads from advances in synthetic planning and methodology
CJ Gerry, SL Schreiber - Nature Reviews Drug Discovery, 2018 - nature.com
Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …
probes of disease-related targets and potential starting points for drug discovery. In this …
Molecular complexity as a driving force for the advancement of organic synthesis
BA Wright, R Sarpong - Nature Reviews Chemistry, 2024 - nature.com
The generation of molecular complexity is a primary goal in the field of synthetic chemistry.
In the context of retrosynthetic analysis, the concept of molecular complexity is central to …
In the context of retrosynthetic analysis, the concept of molecular complexity is central to …
Cell Painting: a decade of discovery and innovation in cellular imaging
Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …
imaging experiments. Image-based profiling leverages the rich information in images to …
Guided by evolution: from biology oriented synthesis to pseudo natural products
Covering: up to 2020 Natural products (NPs) provide inspiration for the design of biologically
active compounds and libraries. In this review, we cover several experimental and in silico …
active compounds and libraries. In this review, we cover several experimental and in silico …
Morphological profiling of small molecules
S Ziegler, S Sievers, H Waldmann - Cell chemical biology, 2021 - cell.com
Profiling approaches such as gene expression or proteome profiling generate small-
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …
High throughput microscopy and single cell phenotypic image-based analysis in toxicology and drug discovery
Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …
environmental toxicants etc.) is of paramount importance to human health as phenotypic …
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Robust, generalizable approaches to identify compounds efficiently with undesirable
mechanisms of action in complex cellular assays remain elusive. Such a process would be …
mechanisms of action in complex cellular assays remain elusive. Such a process would be …
High-throughput synthesis and screening of iridium (III) photocatalysts for the fast and chemoselective dehalogenation of aryl bromides
A high-throughput optical screening method for the photocatalytic activity of a structurally
diverse library of 1152 cationic iridium (III) complexes ([Ir (C^ N) 2 (N^ N)]+), corresponding …
diverse library of 1152 cationic iridium (III) complexes ([Ir (C^ N) 2 (N^ N)]+), corresponding …
Next generation diversity-oriented synthesis: A paradigm shift from chemical diversity to biological diversity
Diversity-oriented synthesis has historically focused on the generation of small-molecule
collections with considerable scaffold, stereochemical, and appendage diversity. Recently …
collections with considerable scaffold, stereochemical, and appendage diversity. Recently …