The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Heterologous pathways used in metabolic engineering may produce intermediates toxic to
the cell. Dynamic control of pathway enzymes could prevent the accumulation of these …

Isoprenoids are the most numerous and structurally diverse family of natural products.
Terpenoids, a class of isoprenoids often isolated from plants, are used as commercial flavor …

Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …

Synthetic biology can significantly advance metabolic engineering by contributing tools
(minimal hosts, vectors, genetic controllers, characterized enzymes). The development of …

Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids
are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl …

Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

Throughout human history, natural products have been the foundation for the discovery and
development of therapeutics used to treat diseases ranging from cardiovascular disease to …

The richness and versatility of biological systems make them ideally suited to solve some of
the world's most significant challenges, such as converting cheap, renewable resources into …