Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

B Jia, H Huang, Z Dong, X Ren, Y Lu… - Chemical Society …, 2024 - pubs.rsc.org
Degradable biomedical elastomers (DBE), characterized by controlled biodegradability,
excellent biocompatibility, tailored elasticity, and favorable network design and …

Biofunctionalization and applications of polymeric nanofibers in tissue engineering and regenerative medicine

P Phutane, D Telange, S Agrawal, M Gunde, K Kotkar… - Polymers, 2023 - mdpi.com
The limited ability of most human tissues to regenerate has necessitated the interventions
namely autograft and allograft, both of which carry the limitations of its own. An alternative to …

Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials

CV Maduka, AD Schmitter-Sánchez… - Nature Biomedical …, 2024 - nature.com
Circulating monocytes infiltrate and coordinate immune responses in tissues surrounding
implanted biomaterials and in other inflamed tissues. Here we show that immunometabolic …

[HTML][HTML] Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism

CV Maduka, AV Makela, A Tundo, E Ural, KB Stivers… - Bioactive Materials, 2024 - Elsevier
Composite biomaterials comprising polylactide (PLA) and hydroxyapatite (HA) are applied
in bone, cartilage and dental regenerative medicine, where HA confers osteoconductive …

The role of multi-walled carbon nanotubes in enhancing the hydrolysis and thermal stability of PLA

JY Diaz Varela, LG Burciaga Jurado… - Scientific Reports, 2024 - nature.com
Polylactic acid (PLA) is a bioresorbable and biodegradable polymer extensively used in
various biomedical and engineering applications. In this study, we investigated the mass …

Behavioral toxicity and neurotoxic mechanisms of PLA-PBAT biodegradable microplastics in zebrafish

D Zhang, X Xu, Y Lu, L Guo - Science of The Total Environment, 2024 - Elsevier
Escalation of ecological concern due to biodegradable plastics has attracted the attention of
many contemporary researchers. This study searched to investigate the acute and sub …

3D-printed biodegradable polycaprolactone rib implants with tissue-specific mechanical properties promote chest wall recovery by stimulating tissue fibrosis

Z Meng, S Yang, F Yin, X Liang, X Yan… - Virtual and Physical …, 2024 - Taylor & Francis
Here we developed a tripartite biodegradable rib implant with tissue-specific mechanical
properties by employing polycaprolactone and a dual-structure-reinforced selective laser …

Stereochemistry determines immune cellular responses to polylactide implants

CV Maduka, M Alhaj, E Ural, MM Kuhnert… - ACS Biomaterials …, 2023 - ACS Publications
Repeating l-and d-chiral configurations determine polylactide (PLA) stereochemistry, which
affects its thermal and physicochemical properties, including degradation profiles. Clinically …

Reversible Intracellular Gelation of MCF10A Cells Enables Programmable Control Over 3D Spheroid Growth

DL McNally, LJ Macdougall… - Advanced …, 2024 - Wiley Online Library
In nature, some organisms survive extreme environments by inducing a biostatic state
wherein cellular contents are effectively vitrified. Recently, a synthetic biostatic state in …

Glycolytic reprogramming underlies immune cell activation by polyethylene wear particles

CV Maduka, OM Habeeb, MM Kuhnert, M Hakun… - Biomaterials …, 2023 - Elsevier
Primary total joint arthroplasties (TJAs) are widely and successfully applied reconstructive
procedures to treat end-stage arthritis. Nearly 50% of TJAs are now performed in young …