Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

AI in health and medicine

P Rajpurkar, E Chen, O Banerjee, EJ Topol - Nature medicine, 2022 - nature.com
Artificial intelligence (AI) is poised to broadly reshape medicine, potentially improving the
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly …

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Redefining critical illness

DM Maslove, B Tang, M Shankar-Hari, PR Lawler… - Nature medicine, 2022 - nature.com
Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

International consensus criteria for pediatric sepsis and septic shock

LJ Schlapbach, RS Watson, LR Sorce, AC Argent… - JAMA, 2024 - jamanetwork.com
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-
specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the …

[HTML][HTML] Features, evaluation, and treatment of coronavirus (COVID-19)

M Cascella - 2020 - ncbi.nlm.nih.gov
Objectives: Screen individuals based on exposure and symptom criteria to identify potential
COVID-19 cases. Identify the clinical features and radiological findings expected in patients …

Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost

N Hou, M Li, L He, B **e, L Wang, R Zhang… - Journal of translational …, 2020 - Springer
Background Sepsis is a significant cause of mortality in-hospital, especially in ICU patients.
Early prediction of sepsis is essential, as prompt and appropriate treatment can improve …

Sepsis and septic shock

NJ Meyer, HC Prescott - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Sepsis and Septic Shock Sepsis is a syndrome of life-threatening acute organ
dysfunction due to bacterial, fungal, parasitic, or viral infection. Factors that affect the risk of …

[HTML][HTML] A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock… - Cell, 2022 - cell.com
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …