Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

International consensus criteria for pediatric sepsis and septic shock

LJ Schlapbach, RS Watson, LR Sorce, AC Argent… - Jama, 2024 - jamanetwork.com
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-
specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the …

AI in health and medicine

P Rajpurkar, E Chen, O Banerjee, EJ Topol - Nature medicine, 2022 - nature.com
Artificial intelligence (AI) is poised to broadly reshape medicine, potentially improving the
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly …

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Redefining critical illness

DM Maslove, B Tang, M Shankar-Hari, PR Lawler… - Nature medicine, 2022 - nature.com
Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

Immune dysregulation in sepsis: experiences, lessons and perspectives

M Cao, G Wang, J **e - Cell death discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials

P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

[HTML][HTML] Features, evaluation, and treatment of coronavirus (COVID-19)

M Cascella, M Rajnik, A Aleem, SC Dulebohn… - 2020 - europepmc.org
Objectives: Screen individuals based on exposure and symptom criteria to identify potential
COVID-19 cases. Identify the clinical features and radiological findings expected in patients …