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Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …
The pathophysiology of sepsis and precision-medicine-based immunotherapy
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …
countries. Antibiotic therapy and supportive care have significantly improved survival …
International consensus criteria for pediatric sepsis and septic shock
LJ Schlapbach, RS Watson, LR Sorce, AC Argent… - Jama, 2024 - jamanetwork.com
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-
specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the …
specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the …
AI in health and medicine
Artificial intelligence (AI) is poised to broadly reshape medicine, potentially improving the
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly …
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly …
The immunology of sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …
response to an infection. This recently implemented definition does not capture the …
Redefining critical illness
Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …
Immune dysregulation in sepsis: experiences, lessons and perspectives
M Cao, G Wang, J **e - Cell death discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
[HTML][HTML] Features, evaluation, and treatment of coronavirus (COVID-19)
M Cascella, M Rajnik, A Aleem, SC Dulebohn… - 2020 - europepmc.org
Objectives: Screen individuals based on exposure and symptom criteria to identify potential
COVID-19 cases. Identify the clinical features and radiological findings expected in patients …
COVID-19 cases. Identify the clinical features and radiological findings expected in patients …