Natural biomaterials for cardiac tissue engineering: a highly biocompatible solution
Cardiovascular diseases (CVD) constitute a major fraction of the current major global
diseases and lead to about 30% of the deaths, ie, 17.9 million deaths per year. CVD include …
diseases and lead to about 30% of the deaths, ie, 17.9 million deaths per year. CVD include …
3D cardiac cell culture: a critical review of current technologies and applications
C Zup**er - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Three-dimensional (3D) cell culture is often mentioned in the context of regenerative
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …
Generation of functional human 3D cortico-motor assembloids
Neurons in the cerebral cortex connect through descending pathways to hindbrain and
spinal cord to activate muscle and generate movement. Although components of this …
spinal cord to activate muscle and generate movement. Although components of this …
Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels
Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …
Human engineered heart tissue patches remuscularize the injured heart in a dose-dependent manner
E Querdel, M Reinsch, L Castro, D Köse, A Bähr… - Circulation, 2021 - Am Heart Assoc
Background: Human engineered heart tissue (EHT) transplantation represents a potential
regenerative strategy for patients with heart failure and has been successful in preclinical …
regenerative strategy for patients with heart failure and has been successful in preclinical …
Imaging cellular forces with photonic crystals
Current techniques for visualizing and quantifying cellular forces have limitations in live cell
imaging, throughput, and multi-scale analysis, which impede progress in cell force research …
imaging, throughput, and multi-scale analysis, which impede progress in cell force research …
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
M Abulaiti, Y Yalikun, K Murata, A Sato, MM Sami… - Scientific reports, 2020 - nature.com
Human iPS cell (iPSC)-derived cardiomyocytes (CMs) hold promise for drug discovery for
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
3D co-culture of hiPSC-derived cardiomyocytes with cardiac fibroblasts improves tissue-like features of cardiac spheroids
P Beauchamp, CB Jackson, LC Ozhathil… - Frontiers in molecular …, 2020 - frontiersin.org
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin
X Qiao, SY van der Zanden… - Proceedings of the …, 2020 - National Acad Sciences
The anthracycline doxorubicin (Doxo) and its analogs daunorubicin (Daun), epirubicin (Epi),
and idarubicin (Ida) have been cornerstones of anticancer therapy for nearly five decades …
and idarubicin (Ida) have been cornerstones of anticancer therapy for nearly five decades …