Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many
countries for treatment of cerebrovascular disorders such as stroke and dementia for more …

Deficits in brain function that are associated with aging and age-related diseases benefit
very little from currently available therapies, suggesting a better understanding of the …

Environmental toxins are harmful substances detrimental to humans. Constant exposure to
these fatal neurotoxins can cause various neurodegenerative disorders. Although …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recent
studies have investigated the involvement of epigenetic modifications in PD. Histone …

Parkinson's disease (PD) is manifested by progressive motor, autonomic, and cognitive
disturbances. Dopamine (DA) synthesizing neurons in the substantia nigra (SN) degenerate …

Cyclic nucleotide phosphodiesterase (PDE) enzymes catalyze the hydrolysis and
inactivation of the cyclic nucleotides cyclic adenosine monophosphate and cyclic guanosine …

The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …

The derivation of dopaminergic neurons from induced pluripotent stem cells brings new
hope for a patient-specific, stem cell-based replacement therapy to treat Parkinson's disease …

Abstract α-synuclein-induced neurotoxicity is a core pathogenic event in neurodegenerative
synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, or multiple …

Neurodegenerative diseases (NDs) cause progressive loss of neuron structure and
ultimately lead to neuronal cell death. Since the available drugs show only limited …