Certain infectious diseases caused by pathogenic bacteria are typically chronic in nature.
Potentially deadly examples include tuberculosis, caused by Mycobacterium tuberculosis …

Critical to meeting cellular phosphorus (P) demand, soil bacteria deploy a number of
strategies to overcome limitation in inorganic P (Pi) in soils. As a significant contributor to P …

Inorganic phosphate (Pi) is an essential component of all life forms. Land plants acquire Pi
from the soil through roots and associated symbioses, and it is then transported throughout …

Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition
to this essential role in energy metabolism, the tricarboxylate anion also acts as both a …

Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential
roles in metabolic signaling and cellular regulation. These di-and tricarboxylates are …

Apicomplexa are important pathogens that include the causative agents of malaria,
toxoplasmosis, and cryptosporidiosis. Apicomplexan parasites contain a relict chloroplast …

The planktonic synthesis of reduced organophosphorus molecules, such as
alkylphosphonates and aminophosphonates, represents one half of a vast global oceanic …

Membrane transporters actively translocate their substrate by undergoing large-scale
structural transitions between inward-(IF) and outward-facing (OF) states ('alternating …

Antimicrobial resistance is well-known to be a global health and development threat. Due to
the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as …

Membrane transporters rely on highly coordinated structural transitions between major
conformational states for their function, to prevent simultaneous access of the substrate …