[HTML][HTML] An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

[HTML][HTML] The translational challenge in Chagas disease drug development

JM Kratz, KR Gonçalves, L Romera… - Memorias do Instituto …, 2022 - SciELO Brasil
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …

Current leishmaniasis drug discovery

AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …

[HTML][HTML] Recent progress in the development of indole-based compounds active against malaria, trypanosomiasis and leishmaniasis

PAF Pacheco, MMM Santos - Molecules, 2022 - mdpi.com
Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Liposomal drug delivery systems for the treatment of leishmaniasis

FF Tuon, LR Dantas, RM de Souza, VST Ribeiro… - Parasitology …, 2022 - Springer
Human le ishmaniasis is a vector-borne, neglected infectious disease that is widely
distributed in America, Africa, Europe, and Asia. Current therapy is based on old and toxic …

[HTML][HTML] Effects of propolis on infectious diseases of medical relevance

N Rivera-Yanez, CR Rivera-Yanez, G Pozo-Molina… - Biology, 2021 - mdpi.com
Simple Summary Propolis is a beekee** product with a complex and highly variable
chemical composition. Many beneficial health properties have been reported. In this review …

Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects

OF Davies-Bolorunduro, O Osuolale, S Saibu… - Heliyon, 2021 - cell.com
Revived analysis interests in natural products in the hope of discovering new and novel
antileishmanial drug leads have been driven partially by the increasing incidence of drug …

Leishmania Animal Models Used in Drug Discovery: A Systematic Review

J van der Ende, HDFH Schallig - Animals, 2023 - mdpi.com
Simple Summary Animals are frequently used to determine whether new compounds have
the potential to be used as drugs against the parasitic disease leishmaniasis. There is …

Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?

M Marín, M López, L Gallego‐Yerga… - Medicinal Research …, 2024 - Wiley Online Library
Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Approved drugs successfully repurposed against Leishmania based on machine learning predictions

R Oualha, YZ Abdelkrim, I Guizani… - Frontiers in Cellular …, 2024 - frontiersin.org
Drug repurposing is a promising approach towards the discovery of novel treatments against
Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing …