Persistent immune imprinting occurs after vaccination with the COVID-19 XBB. 1.5 mRNA booster in humans

MA Tortorici, A Addetia, AJ Seo, J Brown, K Sprouse… - Immunity, 2024 - cell.com
Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …

Neutralization, effector function and immune imprinting of Omicron variants

A Addetia, L Piccoli, JB Case, YJ Park, M Beltramello… - Nature, 2023 - nature.com
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

Leveraging deep learning to improve vaccine design

AP Hederman, ME Ackerman - Trends in immunology, 2023 - cell.com
Deep learning has led to incredible breakthroughs in areas of research, from self-driving
vehicles to solutions, to formal mathematical proofs. In the biomedical sciences, however …

Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

L Zhong, W Zhang, C Krummenacher, Y Chen… - Trends in …, 2023 - cell.com
Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

Q ** immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans
A Addetia, C Stewart, AJ Seo, KR Sprouse, AY Asiri… - Cell Reports, 2024 - cell.com
Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012 and
causes human infections in endemic regions. Vaccines and therapeutics in development …

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

J Lee, SK Zepeda, YJ Park, AL Taylor, J Quispe… - Cell Host & Microbe, 2023 - cell.com
Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …