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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB. 1.5 mRNA booster in humans
Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …
Neutralization, effector function and immune imprinting of Omicron variants
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …
Leveraging deep learning to improve vaccine design
AP Hederman, ME Ackerman - Trends in immunology, 2023 - cell.com
Deep learning has led to incredible breakthroughs in areas of research, from self-driving
vehicles to solutions, to formal mathematical proofs. In the biomedical sciences, however …
vehicles to solutions, to formal mathematical proofs. In the biomedical sciences, however …
Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents
Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
Q ** immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans
Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012 and
causes human infections in endemic regions. Vaccines and therapeutics in development …
causes human infections in endemic regions. Vaccines and therapeutics in development …
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
J Lee, SK Zepeda, YJ Park, AL Taylor, J Quispe… - Cell Host & Microbe, 2023 - cell.com
Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …