During ageing, the secretory patterns of the hormones produced by the hypothalamic–
pituitary axis change, as does the sensitivity of the axis to negative feedback by end …

Background: Atrial fibrillation (AF) is a highly prevalent disorder leading to heart failure,
stroke, and death. Enhanced understanding of modifiable risk factors may yield …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Thyroid hormones have long been known to have a range of effects on the cardiovascular
system. However, significant knowledge gaps exist concerning the precise molecular and …

Importance In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as
causal and treatable factors for cognitive decline. However, the scientific literature on these …

Hypothyroidism means an underactive thyroid gland. This leads to a decrease in the
functioning of the thyroid gland. It is a very common endocrine disorder that causes under …

Background: Reference ranges for serum thyrotropin (TSH), free thyroxine (fT4), and free
triiodothyronine (fT3) established without considering age-and sex-based differences are …

Rationale: Thyroid hormones have been linked with various proatherogenic and
antiatherogenic processes. However, the relationship of thyroid function with manifestations …