CaM kinase: still inspiring at 40
KU Bayer, H Schulman - Neuron, 2019 - cell.com
Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …
Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
Calcium/calmodulin-stimulated protein kinase II (CaMKII): different functional outcomes from activation, depending on the cellular microenvironment
JAP Rostas, KA Skelding - Cells, 2023 - mdpi.com
Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a family of broad substrate
specificity serine (Ser)/threonine (Thr) protein kinases widely expressed in many tissues that …
specificity serine (Ser)/threonine (Thr) protein kinases widely expressed in many tissues that …
Synaptic memory requires CaMKII
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and
memory. While the mechanisms underlying the induction of LTP ('learning') are well …
memory. While the mechanisms underlying the induction of LTP ('learning') are well …
Synaptic memory survives molecular turnover
J Lee, X Chen, RA Nicoll - Proceedings of the National …, 2022 - National Acad Sciences
Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) plays a critical role in long-term
potentiation (LTP), a long accepted cellular model for learning and memory. However, how …
potentiation (LTP), a long accepted cellular model for learning and memory. However, how …
CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
The dodecameric protein kinase CaMKII is expressed throughout the body. The alpha
isoform is responsible for synaptic plasticity and participates in memory through its …
isoform is responsible for synaptic plasticity and participates in memory through its …
Reciprocal activation within a kinase-effector complex underlying persistence of structural LTP
T Saneyoshi, H Matsuno, A Suzuki, H Murakoshi… - Neuron, 2019 - cell.com
Long-term synaptic plasticity requires a mechanism that converts short Ca 2+ pulses into
persistent biochemical signaling to maintain changes in the synaptic structure and function …
persistent biochemical signaling to maintain changes in the synaptic structure and function …
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Ca2+/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal
signaling protein and an emerging drug target. The central hub domain regulates the activity …
signaling protein and an emerging drug target. The central hub domain regulates the activity …
Structure and assembly of calcium homeostasis modulator proteins
The biological membranes of many cell types contain large-pore channels through which a
wide variety of ions and metabolites permeate. Examples include connexin, innexin and …
wide variety of ions and metabolites permeate. Examples include connexin, innexin and …
Adaptation of Plants to Salt Stress: Characterization of Na+ and K+ Transporters and Role of CBL Gene Family in Regulating Salt Stress Response
Salinity is one of the most serious factors limiting the productivity of agricultural crops, with
adverse effects on germination, plant vigor, and crop yield. This salinity may be natural or …
adverse effects on germination, plant vigor, and crop yield. This salinity may be natural or …