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Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
J Feng, X Wang, X Ye, I Ares, B Lopez-Torres… - Pharmacological …, 2022 - Elsevier
Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …
Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters
A Sengar, A Vijayanandan - Science of the Total Environment, 2022 - Elsevier
The release of pharmaceuticals and personal care products (PPCPs) in environmental
waters has become an urgent issue due to their pseudo-persistent traits. The present study …
waters has become an urgent issue due to their pseudo-persistent traits. The present study …
Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods
A Balakrishnan, M Sillanpää, MM Jacob… - Environmental Research, 2022 - Elsevier
Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …
Metformin contamination in global waters: Biotic and abiotic transformation, byproduct generation and toxicity, and evaluation as a pharmaceutical indicator
Metformin is the first-line antidiabetic drug and one of the most prescribed medications
worldwide. Because of its ubiquitous occurrence in global waters and demonstrated …
worldwide. Because of its ubiquitous occurrence in global waters and demonstrated …
[HTML][HTML] Occurrence of persistent and mobile chemicals and other contaminants of emerging concern in Spanish and Portuguese wastewater treatment plants …
R Montes, S Méndez, J Cobas, N Carro… - Science of the Total …, 2023 - Elsevier
This work investigated, during one year, the occurrence and fate of 52 contaminants of
emerging concern (CECs) in transnational river basins and coastal areas of the North of …
emerging concern (CECs) in transnational river basins and coastal areas of the North of …
Chitosan/metal organic frameworks for environmental, energy, and bio-medical applications: a review
A Balakrishnan, MM Jacob, N Dayanandan… - Materials …, 2023 - pubs.rsc.org
Chitosan/metal–organic frameworks (CS/MOFs) are versatile materials fabricated by
conjugating the chitosan (CS) material with metal–organic frameworks (MOFs). The …
conjugating the chitosan (CS) material with metal–organic frameworks (MOFs). The …
Recent advances of Clay/polymer-based nanomaterials for the treatment of environmental contaminants in wastewater: A review
Emerging contaminants (ECs) contamination is a pressing issue because of the extensive
utilization of personal care products and antibiotics and the discharging of their effluent to …
utilization of personal care products and antibiotics and the discharging of their effluent to …
The direct targets of metformin in diabetes and beyond
L Yao, L Wang, R Zhang, AA Soukas, L Wu - Trends in Endocrinology & …, 2024 - cell.com
Metformin, an oral antihyperglycemic drug that has been in use for over 60 years, remains a
first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin …
first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin …