Structural insights into the activation mechanism of antimicrobial GBP1

M Weismehl, X Chu, M Kutsch, P Lauterjung… - The EMBO …, 2024 - embopress.org
The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …

Integrative modeling of guanylate binding protein dimers

W Schumann, J Loschwitz, J Reiners… - Protein …, 2023 - Wiley Online Library
Guanylate‐binding proteins (GBPs) are essential interferon‐γ‐activated large GTPases that
play a crucial role in host defense against intracellular bacteria and parasites. While their …

Elucidating the activation mechanism for GBP1 oligomerization

M Weismehl, X Chu, M Kutsch, P Lauterjung… - bioRxiv, 2023 - biorxiv.org
The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defense
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …