Structural insights into the activation mechanism of antimicrobial GBP1
The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …
Integrative modeling of guanylate binding protein dimers
W Schumann, J Loschwitz, J Reiners… - Protein …, 2023 - Wiley Online Library
Guanylate‐binding proteins (GBPs) are essential interferon‐γ‐activated large GTPases that
play a crucial role in host defense against intracellular bacteria and parasites. While their …
play a crucial role in host defense against intracellular bacteria and parasites. While their …
Elucidating the activation mechanism for GBP1 oligomerization
The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defense
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …
against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 …