Nanomaterials as microglia modulators in the treatment of central nervous system disorders

M Battaglini, A Marino, M Montorsi… - Advanced …, 2024 - Wiley Online Library
Microglia play a pivotal role in the central nervous system (CNS) homeostasis, acting as
housekeepers and defenders of the surrounding environment. These cells can elicit their …

Exploration of lipid-based nanocarriers as drug delivery systems in diabetic foot ulcer

B Kandregula, S Narisepalli, D Chitkara… - Molecular …, 2022 - ACS Publications
Diabetes mellitus is a chronic manifestation characterized by high levels of glucose in the
blood resulting in several complications including diabetic wounds and ulcers, which …

Intranasal delivery of nanoparticle encapsulated tarenflurbil: a potential brain targeting strategy for Alzheimer's disease

E Muntimadugu, R Dhommati, A Jain… - European journal of …, 2016 - Elsevier
Poor brain penetration of tarenflurbil (TFB) was one of the major reasons for its failure in
phase III clinical trials conducted on Alzheimer's patients. Thus there is a tremendous need …

Lipid-based nanoparticles for drug-delivery systems

R Kumar - Nanocarriers for drug delivery, 2019 - Elsevier
The discovery of new drug molecules depends on a number of steps, which limits the
development of feasible new drugs for the treatment of disease without any side effects …

Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages

A Costa, B Sarmento, V Seabra - European Journal of Pharmaceutical …, 2018 - Elsevier
Mannose receptor is highly expressed on alveolar macrophages, being a potential target to
promote the specific local drug delivery of anti-tuberculosis agents through the use of …

Nanocarriers for combating biofilms: Advantages and challenges

Y Zhang, S Lin, J Fu, W Zhang, G Shu… - Journal of applied …, 2022 - academic.oup.com
Bacterial biofilms are highly resistant to antibiotics and pose a great threat to human and
animal health. The control and removal of bacterial biofilms have become an important topic …

An emerging technology in lipid research for targeting hydrophilic drugs to the skin in the treatment of hyperpigmentation disorders: kojic acid-solid lipid nanoparticles

K Khezri, M Saeedi, K Morteza-Semnani… - Artificial cells …, 2020 - Taylor & Francis
Kojic acid (KA) as tyrosinase inhibitor shows insufficient skin penetration and several
adverse events due topical administration. KA solid lipid nanoparticles (KA-SLNs) were …

Development and characterization of mucoadhesive buccal gels containing lipid nanoparticles of ibuprofen

AC Marques, AI Rocha, P Leal, M Estanqueiro… - International Journal of …, 2017 - Elsevier
The lipid nanoparticles, namely Nanostructured Lipid Carriers (NLC), as drug delivery
systems have been investigated for several years. One of the delivery routes for which these …

Oxiconazole nitrate solid lipid nanoparticles: formulation, in-vitro characterization and clinical assessment of an analogous loaded carbopol gel

RA Mahmoud, AK Hussein, GA Nasef… - Drug development and …, 2020 - Taylor & Francis
The aim of the present work was to develop a promising drug delivery system of oxiconazole
nitrate-loaded solid lipid nanoparticles (SLNs) topical gel to enhance the drug effectiveness …

A comprehensive review of essential oil–nanotechnology synergy for advanced Dermocosmetic delivery

R Achagar, Z Ait-Touchente, R El Ati, K Boujdi… - Cosmetics, 2024 - mdpi.com
This review investigates the convergence of nanotechnology and essential oils in advanced
dermocosmetic delivery. It outlines the pivotal role of inorganic and polymeric nanoparticles …