Targeting mitochondria with ClpP agonists as a novel therapeutic opportunity in breast cancer

R Wedam, YE Greer, DJ Wisniewski, S Weltz, M Kundu… - Cancers, 2023 - mdpi.com
Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …

Nuclear isoform of RAPH1 interacts with FOXQ1 to promote aggressiveness and radioresistance in breast cancer

Q Liu, Y Cao, X Wei, H Dong, M Cui, S Guan… - Cell Death & …, 2023 - nature.com
Radioresistance limits the efficacy of radiotherapy against breast cancer, especially the most
lethal subtype of breast cancer, triple-negative breast cancer (TNBC). Epithelial-to …

BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy

S Sriramulu, S Thoidingjam, F Siddiqui, SL Brown… - Biomolecules, 2024 - mdpi.com
Simple Summary An inhibitor of BUB1 increases the cytotoxic ability of different classes of
chemotherapy, targeted agents, and radiotherapy in triple-negative breast cancer, which is …

[PDF][PDF] Targeting mitochondria with CLPP agonists as a novel therapeutic opportunity in breast cancer. Cancers, 2023, 15, 1936

R Wedam, YE Greer, DJ Wisniewski, S Weltz, M Kundu… - 2023 - academia.edu
Breast cancer is the most frequently diagnosed malignancy worldwide and the leading
cause of cancer mortality in women. Despite the recent development of new therapeutics …

Investigating radiation therapy treatments with cell cycle and DNA repair inhibitors in triple-negative breast cancer

YC Tsai - 2024 - escholarship.mcgill.ca
Triple-negative breast cancers (TNBCs) are the most aggressive and the deadliest of all
breast cancer molecular subtypes. Patients with TNBCs have limited treatment options and …

Apoptosis induction in breast cancer cells after radiotherapy and potential radiosensitizers

K Simonsson - 2023 - gupea.ub.gu.se
Background. Today breast cancer is the foremost cancer death type amongst women around
the world. At present some of the toughest challenges in the clinic is recurrent, radioresistant …

Nuclear isoform of RAPH1 interacts with FOXQ1 to promote progression and radioresistance in triple-negative breast cancer through the STAT3 pathway

P **ng, Q Liu, Y Cao, X Wei, H Dong, M Cui, S Guan… - 2023 - researchsquare.com
Radioresistance limits the efficacy of radiotherapy against triple-negative breast cancer
(TNBC). Epithelial-to-mesenchymal transition (EMT) is closely related to tumor …