Accelerating antiviral drug discovery: lessons from COVID-19

A Von Delft, MD Hall, AD Kwong, LA Purcell… - Nature Reviews Drug …, 2023 - nature.com
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

P Rodríguez-Morales, RA Franklin - Trends in immunology, 2023 - cell.com
Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

Persistent SARS-CoV-2 infection, EBV, HHV-6 and other factors may contribute to inflammation and autoimmunity in long COVID

A Vojdani, E Vojdani, E Saidara, M Maes - Viruses, 2023 - mdpi.com
A novel syndrome called long-haul COVID or long COVID is increasingly recognized in a
significant percentage of individuals within a few months after infection with SARS-CoV-2 …

Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge

CL Hsieh, SR Leist, EH Miller, L Zhou… - Nature …, 2024 - nature.com
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Develo** a coronavirus vaccine that …

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses

DR Martinez, FR Moreira, NJ Catanzaro… - Science translational …, 2024 - science.org
Despite the wide availability of several safe and effective vaccines that prevent severe
COVID-19, the persistent emergence of severe acute respiratory syndrome coronavirus 2 …

A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae

PM George, A Reed, SR Desai, A Devaraj… - Science translational …, 2022 - science.org
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Animal models of Long Covid: A hit-and-run disease

A Schäfer, SR Leist, JM Powers, RS Baric - Science Translational …, 2024 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused
more than 7 million deaths globally. Despite the presence of infection-and vaccine-induced …

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19

C Li, W Qian, X Wei, H Narasimhan, Y Wu… - Science translational …, 2024 - science.org
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection (PASC) represent an urgent public health challenge and are estimated to affect …

Systems analysis of innate and adaptive immunity in Long COVID

MJ Peluso, M Abdel-Mohsen, TJ Henrich… - Seminars in …, 2024 - Elsevier
Since the onset of the COVID-19 pandemic, significant progress has been made in
develo** effective preventive and therapeutic strategies against severe acute SARS-CoV …