Targeting interleukin-6 signaling in clinic
S Kang, T Tanaka, M Narazaki, T Kishimoto - Immunity, 2019 - cell.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
The molecular details of cytokine signaling via the JAK/STAT pathway
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …
induce inflammation and control the immune response. Cytokines are secreted …
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
The molecular basis of JAK/STAT inhibition by SOCS1
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by
cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by …
cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by …
Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - Elsevier
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
L Zanders, M Kny, A Hahn, S Schmidt… - Journal of cachexia …, 2022 - Wiley Online Library
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …
Inflammation: roles in skeletal muscle atrophy
Y Ji, M Li, M Chang, R Liu, J Qiu, K Wang, C Deng… - Antioxidants, 2022 - mdpi.com
Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …
SOCS3, a major regulator of infection and inflammation
B Carow, ME Rottenberg - Frontiers in immunology, 2014 - frontiersin.org
In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in
modulating the outcome of infections and autoimmune diseases as well as the underlying …
modulating the outcome of infections and autoimmune diseases as well as the underlying …