[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
microRNA strand selection: Unwinding the rules
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation
Circularization was recently recognized to broadly expand transcriptome complexity. Here,
we exploit massive Drosophila total RNA-sequencing data,> 5 billion paired-end reads …
we exploit massive Drosophila total RNA-sequencing data,> 5 billion paired-end reads …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …
transcriptionally regulate the expression of a large fraction of all animal genes and are …
Genome-wide quantitative enhancer activity maps identified by STARR-seq
Genomic enhancers are important regulators of gene expression, but their identification is a
challenge, and methods depend on indirect measures of activity. We developed a method …
challenge, and methods depend on indirect measures of activity. We developed a method …
A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …
past 20 years, determining what is and what is not a miRNA has not been straightforward …
[HTML][HTML] Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development
ER Kingston, LW Blodgett, DP Bartel - Molecular cell, 2022 - cell.com
MicroRNAs (miRNAs) typically direct degradation of their mRNA targets. However, some
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
Most metazoan microRNAs (miRNAs) target many genes for repression, but the nematode
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
Most mammalian mRNAs are conserved targets of microRNAs
MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …