A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

Use of computational fluid dynamics deposition modeling in respiratory drug delivery

PW Longest, K Bass, R Dutta, V Rani… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

[KNJIGA][B] Multiphase flow handbook

E Michaelides, CT Crowe, JD Schwarzkopf - 2016 - books.google.com
The Multiphase Flow Handbook, Second Edition is a thoroughly updated and reorganized
revision of the late Clayton Crowe's work, and provides a detailed look at the basic concepts …

[KNJIGA][B] Computational fluid and particle dynamics in the human respiratory system

J Tu, K Inthavong, G Ahmadi - 2012 - books.google.com
Traditional research methodologies in the human respiratory system have always been
challenging due to their invasive nature. Recent advances in medical imaging and …

Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway

J **, PW Longest - Annals of biomedical engineering, 2007 - Springer
A number of in vivo, in vitro and numerical studies have considered flow field characteristics
and micro-particle deposition in the oral airway extending from the mouth through the larynx …

In silico models of aerosol delivery to the respiratory tract—Development and applications

PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …

Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract

F Huang, Q Zhu, X Zhou, D Gou, J Yu, R Li… - Advanced drug delivery …, 2021 - Elsevier
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …

Details of regional particle deposition and airflow structures in a realistic model of human tracheobronchial airways: two-phase flow simulation

M Rahimi-Gorji, TB Gorji, M Gorji-Bandpy - Computers in biology and …, 2016 - Elsevier
In the present investigation, detailed two-phase flow modeling of airflow, transport and
deposition of micro-particles (1–10 µm) in a realistic tracheobronchial airway geometry …

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

H Shi, C Kleinstreuer, Z Zhang - Journal of Aerosol Science, 2007 - Elsevier
Nasal inhalation helps to protect the lungs from detrimental effects of toxic particles which,
however, may also place the nasal and adjacent tissues at risk. Alternatively, drug–aerosol …

[KNJIGA][B] Inhalation aerosols: physical and biological basis for therapy

AJ Hickey, HM Mansour - 2019 - books.google.com
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases,
with therapeutic strategies and the range of technology significantly evolving in recent years …