Amino acid composition of proteins reduces deleterious impact of mutations
S Hormoz - Scientific reports, 2013 - nature.com
The evolutionary origin of amino acid occurrence frequencies in proteins (composition) is
not yet fully understood. We suggest that protein composition works alongside the genetic …
not yet fully understood. We suggest that protein composition works alongside the genetic …
Optimisation of asymmetric mutational pressure and selection pressure around the universal genetic code
One of hypotheses explaining the origin of the genetic code assumes that its evolution has
minimised the deleterious effects of mutations in coded proteins. To estimate the level of …
minimised the deleterious effects of mutations in coded proteins. To estimate the level of …
Correspondence between mutation and selection pressure and the genetic code degeneracy in the gene evolution
There are three main elements deciding about the effect of mutations on the protein coding
sequences—the type of the substitution of nucleotide, the selection for the function of the …
sequences—the type of the substitution of nucleotide, the selection for the function of the …
Integrating mRNA and Protein Sequencing Enables the Detection and Quantitative Profiling of Natural Protein Sequence Variants of Populus trichocarpa
Next-generation sequencing has transformed the ability to link genotypes to phenotypes and
facilitates the dissection of genetic contribution to complex traits. However, it is challenging …
facilitates the dissection of genetic contribution to complex traits. However, it is challenging …
The effect of a Pro28Thr point mutation on the local structure and stability of human galactokinase enzyme—a theoretical study
Galactokinase is responsible for the phosphorylation of α-d-galactose, which is an important
step in the metabolism of the latter. Malfunctioning of galactokinase due to a single point …
step in the metabolism of the latter. Malfunctioning of galactokinase due to a single point …
Amino acids exchange in patients with CKD as obtained via exome sequencing differ radically from those of natural variants 1000 genome and genomAD databases
F Fazaludeen, F Saglam - 2023 - researchsquare.com
Background: Nonsynonymous mutations in the coding regions of human genes are
responsible for phenotypic differences between humans and for their susceptibility to …
responsible for phenotypic differences between humans and for their susceptibility to …
Integrating and accessing medical data resources within the ViroLab virtual laboratory
This paper presents the data access solutions which have been developed in the ViroLab
Virtual Laboratory infrastructure to enable medical researchers and practitioners to conduct …
Virtual Laboratory infrastructure to enable medical researchers and practitioners to conduct …
To understand nature-computer modeling between genetics and evolution
D Mackiewicz, S Cebrat - From Genetics To Mathematics, 2009 - World Scientific
We present the basic knowledge on the structure of molecules coding the genetic
information, mechanisms of transfer of this information from DNA to proteins and …
information, mechanisms of transfer of this information from DNA to proteins and …
Representation of mutation pressure and selection pressure by PAM matrices
This paper analyses the relationship between the mutation data matrix 1PAM/PET91,
representing the effect of both mutation and selection pressures exerted on 16 130 …
representing the effect of both mutation and selection pressures exerted on 16 130 …
[PDF][PDF] Mutational and selective mechanisms sha** large-scale organization and evolution of chromosomes
M Kowalczuk, D Mackiewicz, P Mackiewicz, N Polak… - 2005 - open.icm.edu.pl
Sequencing projects provide a lot of information on genome structure, organization and
evolution. Whole-genome analyses reveal large biases in nucleotide composition of genes …
evolution. Whole-genome analyses reveal large biases in nucleotide composition of genes …